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Literature summary extracted from

  • Falany, J.L.; Falany, C.N.
    Interactions of the human cytosolic sulfotransferases and steroid sulfatase in the metabolism of tibolone and raloxifene (2007), J. Steroid Biochem. Mol. Biol., 107, 202-210.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.6.2 medicine benzothiophene sulfates of raloxifene and arzoxifene used as hormone replacement therapeutic agents are hydrolyzed by the enzyme, whereas the raloxifene 4'-phenolic sulfate is resistant. Tissue specific expression of sulfotransferase isoforms and of steroid sulfatase can be important in the inactivation and regeneration of the active form of hormone replacement therapeutic agents Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 arzoxifene sulfate + H2O product of sulfotransferase reaction on arzoxifene used in hormone replacement therapy Homo sapiens arzoxifene + sulfate
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 ?
3.1.6.2 additional information no substrate: tibolone 17-sulfate Homo sapiens ?
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 ?
3.1.6.2 raloxifene sulfate + H2O product of sulfotransferase reaction on raloxifene used in hormone replacement therapy, the benzothiophene sulfate is substrate, the 4'-phenolic sulfate is no substrate for enzyme Homo sapiens raloxifene + sulfate
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 ?